Conquest of Ebola in Humans and Animals

Henao-Restrepo et al. report the final results of a large efficacy trial of a novel, live attenuated vaccine against Ebola conducted in 2015 in the Republic of Guinea (Lancet, Published online December 22, 2016, http://dx.doi.org/10.1016/S0140-6736(16)32621-6). A single inoculation of the vaccine proved 100% effective in preventing Ebola virus disease. The trial was conducted under the leadership of the World Health Organization, in difficult circumstances during the large West African epidemic underway at the time and utilized a ring vaccination strategy which is described in detail in the publication.